A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases

Abstract Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial anti-cancer agents one the most significant challenges that restrict their activity. Therefore, it necessary increase doses or combinations. However, introducing drugs in this way ineffective due poor solubility, low bioavailability, reduced stability, different pharmacokinetic parameters. Vesicular nanocarriers considered promising for effective delivery overcoming resistance. Lipid-based systems (LBDDS) such as emulsomes (EMLs) can solve many problems physicochemical properties. EMLs share structural similarities liposomes solid lipid nanoparticles (SLNs). main components emulsomal preparation triglycerides (TG), phospholipids (PC), cholesterol (Chol). These provide greater stability parameters vivo compared other lipid-based systems, limitations surpassing shortcomings. This review offers a broad summary research date comprehensive overview formulation materials effects on fabrication, physical characteristics, surface modification, lymphatic targeting, recent applications infectious diseases. offer stable safe adequate entrapment sustained release properties, improving bioavailability evading multidrug Furthermore, they hold promise future clinical drugs. Graphical